8:00 am Registration & Morning Coffee
8:55 am Chair’s Opening Remarks
Revolutionizing Pairing Technologies: Overcoming Challenges in Antibody Screening & Compatibility
9:00 am Mastermind: Next-Generation Sequencing for Antibody Repertoire Analysis: Creative Approaches & Analytical Insights
Synopsis
- Addressing the challenges in obtaining diverse antibody repertoires for discovery and engineering
- Discussing the use of next-generation sequencing techniques for both bulk and single-cell analysis in understanding immune responses
- Exploring innovative approaches to obtaining diverse antibody repertoires for discovery
9:30 am Revolutionizing Antibody Screening Through Automation
Synopsis
- Explore the transformative power of automation in antibody screening, spotlighting its pivotal role in high-throughput screening processes
- Uncover the critical need for reliability and error mitigation and delve into strategies including system suitability tests and contingency protocols to overcome these hurdles and ensure robust screening outcomes
- Gain practical guidance for individuals embarking on their journey into antibody screening automation
10:00 am Morning Break & Speed Networking
Synopsis
Our speed networking is the ideal opportunity to get face-to-face time with the brightest minds working in engineering and developability and introduce yourself to the attendees that you would like to have more in-depth conversations with. Benchmark against industry leaders and establish meaningful business relationships to pursue for the conference and beyond.
11:00 am Exploring a Deep Screening Platform & High Throughput Processes to Improve AI Capabilities
Synopsis
- Understanding how characterization and purification data can feedback into AI & machine learning
- Assessing how developability advancement can improve machine learning abilities
11:30 am High-Throughput Production & Analytics Workflows for Multispecifics: From Hundreds to a Single Lead
Synopsis
- Exploring how to support from screening stage to larger scales for DMPK and toxicology studies
- Navigate how to determine mis-pairing and understand productivity
- Leverage analytical insights to provide a complete picture and mitigate mis-pairings
Reducing Unpredictability, Trial-&-Error Tactics, & Complexity in Antibody Engineering
12:00 pm Exploring How Bispecific Design Elements Impact Purity
Synopsis
- Exploring strategies to optimize purity with a variety of design elements
- Assessing how to test the design elements and resulting impact on purity
- Gathering the correct data to inform decisions for further process development
12:30 pm Lunch & Networking
1:30 pm Exploring a Trispecific T Cell Engager Platforms
Synopsis
- Delve into the TriTCE Co-Stim (αCD3xαCD28xαTAA) and TriTCE CPI (αCD3xPD1xαTAA) programs
- Explore engineering and screening solutions to identify differentiated trispecific antibodies
- Utilize these programs to widen the therapeutic index to address hard-to-treat cancers
2:00 pm Innovations in Bi-Specific & Multi-Specific Antibodies: Navigating Challenges & Enhancing Therapeutic Efficacy
Synopsis
- Exploring the rationale behind moving beyond traditional monospecific antibodies
- Addressing the complexities involved in developing Bi-Specific Antibodies
- Discussing strategies and innovations to overcome challenges in the development process
2:30 pm Innovations in Navigating Novel Platforms and Development Challenges
Synopsis
- Navigating the path from bench to clinic by ensuring optimal expression and stability of novel domains
- Utilizing protein engineering techniques to facilitate reformatting and enhance developability for clinical application
- Harnessing gathered information to inform decisions on extending half-life and enhancing therapeutic efficacy
3:30 pm Afternoon Break & Poster Session
Revolutionizing Drug Development Target & Cross-Disciplinary Collaboration
4:30 pm Panel Discussion: Machine Learning in Antibody Engineering: Current Challenges & Future Prospects
Synopsis
- Exploring the potential of machine learning in optimizing the Antibody discovery and engineering process
- Discussing the challenges, particularly in acquiring and formatting the necessary data for effective machine learning
- Addressing the challenges and opportunities each company size faces in leveraging tools like machine learning
4:45 pm Navigating the Complexity & Developability Challenges in Multispecific Antibody Therapeutics
Synopsis
- Understanding the transition from monovalent to multivalent formats in antibody development
- Importance of comprehensive developability assessment in choosing clinical candidates
- Strategies for successful characterization and production of multispecific antibody therapeutics